Abveris' Berkeley Lights Beacon-based single B cell screening platform enables rapid screening and identification of functional antibodies (picture below). This function-forward single B cell workflow can screen 10Ks to 100Ks of antibodies with 4x the resolution of other B cell screening technologies on the market in ONE day. Using the Beacon, our antibody discovery experts exhaustively screen each and every B cell for binding and function using an arsenal of cell-based and bead-based assay formats to rapidly focus on the most promising antibody candidates before the completion of a single day of screening. High-resolution screening data better inform decisions on which clones to advance to the next stage, resulting in significant overall cost and time savings for the antibody discovery process. In conjunction with our DiversimAb technology, this workflow is poised to be a powerhouse for the discovery of diverse functional hits against challenging targets, based on the broadened epitopic and sequence diversity of DiversimAb antibodies.
During a recent webinar of "Accelerated Discovery of Functionally Relevant Antibodies Leveraging Broadened Epitopic Diversity And Single B Cell Screening " our CEO, Tracey Mullen presents a case study from a therapeutic mAb discovery campaign. In this campaign, our DiversimAb hyperimmune mice and Beacon B cell screening platform are combined to rapidly identify a panel of fully validated, highly specific ligand-blocking antibodies in just over two months.
To learn more about the accelerated discovery services we provide to our partners, please visit our technical resource page.