Abveris and Berkeley Lights have published a joint application note on Rapid High-Resolution Screening of Plasma B Cells to Identify Antibody Lead Candidates. This document covers a variety of applications and cutting-edge cell-based assays developed by Abveris using Berkeley Lights's Beacon platform. The following contents are discussed in the note:
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Deliver anti-idiotypic antibodies with competitive ligand-blocking activity in half the time of a traditional hybridoma screen
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Discover a diverse panel of rare, high-affinity antibodies that could not be discovered using phage display against an antigen with a completely homologous off-target product
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Develop an adherent cell-based binding assay that enables discovery of lead candidate sequences against a challenging membrane-bound target in just 29 days