Anti-idiotypic Antibody Discovery

The industry-leading platform for delivery of assay-ready anti-idiotypic antibody reagents

Anti-Idiotypic Antibody Discovery Services

With Abveris anti-idiotypic antibody discovery services, you get delivery of ideal anti-idiotypic monoclonal antibodies for PK/ADA assays using proprietary technology and industry-leading workflow.

Anti-Idiotypic Ab (Anti-ID)

A quick review on anti-ID structure

Abveris Anti-ID Ab Program

Features & Advantages

Abveris Anti-ID Ab Program

Workflow & Processes

Abveris Anti-ID Ab Program

Anti-ID Ab Discovery Case Study

What are anti-idiotypic antibodies?

Anti-idiotypic antibodies are antibodies that bind to the antigen-binding site of another antibody or biologic. Anti-idiotypic antibodies are important downstream reagents for specific drug development assays (e.g. PK and ADA), as well as many other applications such as diagnostic assays and biomarker discovery & evaluation.

There are different ways an anti-idiotypic antibody can interact with an antibody via different regions (Figure 1). The key success factor for the development is the understanding of the intended applications and design of proper screening cascades for the selection of ideal anti-idiotypic antibodies. Abveris develops industry-leading technologies and workflows that will drastically enhance the success of anti-idiotypic antibody discovery campaigns.

Idiotope:

Antigenic determinant in & near CDRs

Paratope:

Part of antibody that recognizes antigen

Epitope:

Part of antigen to which paratope binds

Blocking & non-blocking anti-ids are useful for assay development.

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Figure 1. Illustration of an antibody structure highlighting the variable regions.

Watch our anti-idiotypic antibody discovery webinar

Features of Abveris Anti-idiotype discovery

Superior Antibody Diversity

Abveris's platform produces a diverse panel of specific anti-idiotypic antibodies using our proprietary hyperimmune DiversimAb^TM Mouse

Advanced Affinity and Specificity Screenings

Industry-leading stringent, function-forward screening package including BOTH Octet BLI and ELISA.
All delivered Anti-idiotype mAbs are screened for binding in the presence of human serum by ELISA and for affinity on Octet to deliver ideal mAbs for downstream use

Rapid, Predictable Project Timelines

Abveris devises an industry-leading anti-idiotypic antibody discovery platform that offers both single B cell screening and integrated hybridoma workflows to significantly de-risk projects and improves the predictability of timelines vs. other discovery workflows.

Proven Expertise and 96% Success Rate

100+ successful anti-idiotypic antibody programs
96% success rate based on project requirements
Success in different therapeutic modalities, including monoclonal antibodies, bispecifics, ADC, and cell therapy products such as CAR-T and CAT-NK

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Selected Assays Supported by Abveris Anti-Idiotypic Antibodies

Our Anti-Id GUARANTEE:

Our anti-id guarantee promises delivery of anti-idiotypic antibodies capable of specific binding to target biologic. If we don’t find at least one, we will perform an additional screen for FREE.

Targeting diverse biologics frameworks

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Advantages of Abveris anti-antibodies Service

Rapid Discovery

2.5 months from immunization start to HC/LC sequence and validated, purified mAb via B cell screening

Tailored Performance

High specificity and affinity driven by early-on advanced screenings

Superior Success Rate

A proven track record for even the most challenging projects

ANTI-IDIOTYPIC ANTIBODY PLATFORM

Learn more about our anti-idiotypic antibody platform with custom-tailored workflows:

Anti-idiotypic antibody platform with custom-tailored workflows

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learn more about Abveris's anti-idiotype antibody discovery programs

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Case Study 1:

Hybridoma-Based Anti-ID Campaign for a Bispecific Therapeutic

Antibody Banner - Tracey Mullen Interview

Case Study 2:

Ultrafast Single B Cell-Based Anti-ID Antibody Discovery

Case Study 3:

Identifying Specific mAb Binders to a CAR, Enabling Drug Quantification in Patient Serum Sample

Contact Abveris for Anti-Idiotypic Antibody Discovery

Anti-idiotypic Antibody Discovery

The industry-leading platform for delivery of assay-ready anti-idiotypic antibody reagents