What are anti-idiotypic antibodies?
Anti-idiotypic antibodies are antibodies that bind to the antigen binding site of another antibody or biologic. Anti-idiotypic antibodies are important downstream reagents for specific drug development assays (e.g. PK and ADA), as well as many other applications such as diagnostic assays and biomarker discovery & evaluation.
There are different ways an anti-idiotypic antibody can interact with an antibody via different regions (Figure 1). The key success factor for the development is the understanding of the intended applications and design of proper screening cascades for the selection of ideal anti-idiotypic antibodies. Abveris develops industry-leading technologies and workflows that will drastically enhance the success of anti-idiotypic antibody discovery campaigns.
Antigenic determinant in & near CDRs
Part of antibody that recognizes antigen
Part of antigen to which paratope binds
Blocking & non-blocking anti-ids are useful for assay development.
Figure 1. Illustration of an antibody structure highlighting the variable regions.
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